141Lu Fibrotic NSIP possible

  • 70 y.o. male with history notable for: emphysema/pulmonary fibrosis on home O2 (3L at rest, 4L with exertion), previous smoker (quit 10 years ago), severe OSA compliant with CPAP, arthritis, chronic rash, BPH who presents for follow-up.
  • recently undergone a pharmacologic stress test
    • no evidence of ischemia. He continued to have baseline dyspnea on exertion,
    • reduced DLCO on PFTs.
    • of recent
      • significant decline in his respiratory status.
      • rheumatology and had a serologic work-up completed that was inconsistent with any one diagnosis.
      • increasing supplemental oxygen and is now on 3L at rest and 4L with exertion.
      • stops after every 4 steps
      • no chest pain or palpitations.
    • TTE 2 years ago
      • Normal LV cavity size, with
      • mildly increased wall thickness,
      • normal global systolic function.
        • Calculated LVEF is 57%
        • Normal RV size and global RV systolic function.
        • Moderately dilated LA size (43 mL/m^2).
    • rheum workup with
      • + ANA /Cryo , referred to rheumatology
    • CXR current

      70M NSIP fibrotic 001 CXR decreased vol fibrosis PAH
    • Chest CT
    • 70M NSIP fibrotic 002 CT current subpleural fibrosis

      • COPD/subpleural fibrosis.
      • Subpleural groundglass opacity
      • bilateral reticulations
      • slightly worse lower lobes.
      • traction bronchiolectasis in the lower lobes.
      • No honeycombing is visualized.
      • suggestive of interstitial lung disease with a
        • NSIP pattern.
        • Findings are stable since 2 years ago
          have progressed over 7years
        • Mild upper lobe centrilobular emphysema
        • Enlarged main pulmonary artery measuring 4.3 cm indicating pulmonary hypertension