Common Variable Immunodeficiency (CVID)

  • is an impaired immune system
    • most common symptomatic primary immunodeficiency
  • caused by
    • mostly unknown
    • <10%  genetic
  • resulting in
    • recurrent respiratory tract infections.
    • Cellular changes
      • serum IgA and IgG: decreased but not absent
      • serum IgM: occasionally decreased
      • circulating T and B lymphocytes: present
    • Organs
      • skin
      • sinuses
      • lung
        • bronchiectasis withILD
        • ~10% of patients  a systemic granulomatous disease
        • pulmonary nodules
        • ground glass changes
        • lung parenchymal opacification: may be multifocal
        • other features
          • intrathoracic or intra-abdominal lymphadenopathy and/ or hepatosplenomegaly
      • liver
      • hematologic
  • TCV