Systemic Disease and Lungs

  • Sarcoidosis
      • Position
        •  predominance of the upper and middle lung zones;
        • clustered in the perihilar and peribronchovascular
        • sparing of the lung periphery
        • perilymphatic distribution
          • in relation to the subpleural surface,
          • adjacent to the major fissures,
          • along thickened interlobular septa, and
          • adjacent to vessels in the lobular core
      • Nodules
        • well-defined nodules
        • sometimes becoming confluent – galaxy sign
        • conglomerate masses
      • Lymphadenopathy
        • egg shell
        • amorphous “icing sugar”
      • Fibrosis
        • traction bronchiectasis
        • honeycombing
        • bullae
        • volume loss upper lobes
  • Connective Tissue Disorders
  • RA
  • Scleroderma
  • SLE
  • Polymyosistis and dermatomyosistis
  • Vasculitis
  • Granulomatosis with polyangiitis
  • Microscopic polyangiitis 
  • Eosinophilic granulomatosis with polyangiitis
  • Pulmonary sarcoidosi
  • Collagen vascular diseases 
  • Sjögren syndrome 
  • Mixed connective tissue disease 
  • Pulmonary vasculitis/diffuse alveolar hemorrhage 
  • ANCA-associated granulomatous vasculitis (former Wegener granulomatosis) 
  • Churg Strauss 
  • Goodpasture syndrome
  •  Inflammatory bowel disease 
  • Amyloidosis 

 

 

References and Links

Schaefer-Prokop C et al  Pulmonary Manifestations of Systemic Diseases Diseases of the Chest, Breast, Heart and Vessels 2019-2022 pp 127-138