• 40y.o. male recently diagnosed with atypical chronic myeloid leukemia (aCML) after presenting with fevers and malaise
• Associated findings
  • Splenomegaly 15.5 cm
  • transfusion-dependent macrocytic anemia and
  • 10% circulating blasts with myeloid phenotype
  • bone marrow biopsy
    • suggested myeloproliferative disorder rather than AML,
      • most consistent with CML,
        • BCR/ABL1 FISH negative.
        • Recommendation
          • Stem cell Tx and
          • Venetoclax
          • Inqovi
    • CXR 3 MONTHS AGO AT TIME OF PRESENTATION

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      3 months later after starting chemotherapy

    • complained of dyspnea
    • CXR
      •  CXR post chemo shows left lower lobe subsegmental infiltrate and prominent interstitial changes at the bases
    • CT scan
    • subsegmental consolidative opacity in the left lower
      lobe in a background of
      • diffuse bilateral segmental and subsegmental
        airway disease
      • groundglass changes
      • mosaic attenuations and
      • some nodular
        infiltrates.
    • Infectious, inflammatory immunologic (lung toxicity ) etiologies are considered

 

CT Scan