251Lu Acute Inhalational Pneumonitis with Crazy Paving

2 Years Prior to Current Admission

55-year-old male with
substance use disorder presents with  dyspnea.
Mild Upper Lobe ground Glass Changes

CT 2 Years Prior Minor Upper Lobe Ground Glass Changes
55 year old male with substance use disorder presented 2years prior with dyspnea. CT in the axial plane shows minor ground glass changes in the upper lobes. Inhalational alveolitis was suspected
Ashley Davidoff MD TheCommonVein.net 251Lu 135914
CT 2 Years Prior Minor Upper Lobe Ground Glass Changes
55 year old male with substance use disorder presented 2years prior with dyspnea. CT in the axial plane shows minor ground glass changes in the upper lobes. Inhalational alveolitis was suspected
Ashley Davidoff MD TheCommonVein.net 251Lu 135915

CT 18 months Later

  • 55 y.o. male w
  • PMH of AUD c/b chronic pancreatitis, HTN, obstructive lung disease (COPD, asthma) tobacco use disorder,
  • Presents with
    • 1 day of abdominal pain and nausea
    • found to have presumed alcohol induced pancreatitis. During hospitalization, patient noted to have elevated CK,
    •   Lipase 345, acute on chronic pancreatitis,
    • Elevated transaminases in pattern of hepatocellular injury, AST 870, ALT 541. Normal bilirubin
    • worsening SOB and new hypoxemia.
    • worsening GGOs on imaging.

CT – more prominent
Central, perihilar upper lobe ground glass changes.
Inhalational pneumonitis 

CT 18 months Later – Prominent Upper Lobe Ground Glass Changes
55-year-old male with substance use disorder presents with progressive dyspnea. Axial CT shows more prominent central, and upper lobe ground glass changes. Inhalational pneumonitis was suspected from cigarette smoking or from inhaled cocaine . Included in the differential diagnosis was DIP and hypersensitivity pneumonitis
Ashley Davidoff MD TheCommonVein.net 251Lu 135917
CT 18 months Later – Prominent Upper Lobe Ground Glass Changes
55-year-old male with substance use disorder presents with progressive dyspnea. Magnified view of an axial CT shows panlobular central ground glass changes, with the left upper lobe more prominent than right Inhalational pneumonitis was suspected, from cigarette smoking or cocaine. Included in the differential diagnosis was DIP and hypersensitivity pneumonitis
Ashley Davidoff MD TheCommonVein.net 251Lu 135918
CT 18 months Later – Prominent Upper Lobe Ground Glass Changes
55-year-old male with substance use disorder presents with progressive dyspnea. Coronal CT shows panlobular central ground glass changes, with the left upper lobe more prominent than right. Inhalational pneumonitis was suspected, from cigarette smoking or cocaine. Included in the differential diagnosis was DIP and hypersensitivity pneumonitis
Ashley Davidoff MD TheCommonVein.net 251Lu 135919

1month Later Prominent Upper Lobe
Ground Glass Parenchymal Changes

CXR 1month Later Prominent Upper Lobe Ground Glass Parenchymal Changes
55 year old male with substance use disorder presents with progressive and now more severe dyspnea. Frontal CXR shows extensive upper lobe ground glass changes in the upper lobes. Inhalational pneumonitis was suspected with multifocal regions of consolidation.
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected
Ashley Davidoff MD TheCommonVein.net 251Lu 135918

Prominent Upper Lobe Ground Glass  Parenchymal Changes with Subpleural Sparing

CT 1month Later Prominent Upper Lobe Ground Glass  Parenchymal Changes with Subpleural Sparing
55 year old male with substance use disorder presents with progressive and now more severe dyspnea. CT through the upper lung fields shows extensive upper lobe ground glass changes with thickening of the interlobular septa giving the appearance of “crazy paving”.
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected. DIP and hypersensitivity pneumonitis remained in the differential diagnosis
Ashley Davidoff MD TheCommonVein.net 251Lu 135921
CT 1month Later Prominent Upper Lobe Ground Glass Parenchymal Changes and Subpleural Sparing
55 year old male with substance use disorder presents with progressive and now more severe dyspnea. CT through the upper lung fields shows extensive upper lobe ground glass changes with thickening of the interlobular septa giving the appearance of “crazy paving”. Thickening and irregularity of the left major fissure is also noted
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected. DIP and hypersensitivity pneumonitis remained in the differential diagnosis
Ashley Davidoff MD TheCommonVein.net 251Lu 135922

CT 1month Later Prominent Upper Lob
Ground Glass Parenchymal Changes Crazy Paving  and Subpleural Sparing

CT 1month Later Prominent Upper Lobe Ground Glass Parenchymal Changes Crazy Paving  and Subpleural Sparing
55 year old male with substance use disorder presents with progressive and now more severe dyspnea. CT through the upper lung fields shows extensive upper lobe ground glass changes with thickening of the interlobular septa giving the appearance of “crazy paving”. Thickening and irregularity of the left major fissure is also noted There is bilateral peripheral sparing.
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected. DIP and hypersensitivity pneumonitis remained in the differential diagnosis
Ashley Davidoff MD TheCommonVein.net 251Lu 135923
CT 1month Later Prominent Upper Lobe Ground Glass Parenchymal Changes Crazy Paving  and Subpleural Sparing
55 year old male with substance use disorder presents with progressive and now more severe dyspnea. CT through the upper lung fields shows extensive upper lobe ground glass changes with thickening of the interlobular septa giving the appearance of “crazy paving”. Thickening and irregularity of the left major fissure is also noted There is bilateral peripheral sparing.
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected. DIP and hypersensitivity pneumonitis remained in the differential diagnosis
Ashley Davidoff MD TheCommonVein.net 251Lu 135924
CT 1month Later Prominent Upper Lobe Ground Glass Parenchymal Changes Crazy Paving  and Subpleural Sparing
55 year old male with substance use disorder presents with progressive and now more severe dyspnea. CT through the upper lung fields shows extensive upper lobe ground glass changes with thickening of the interlobular septa giving the appearance of “crazy paving”. Thickening and irregularity of the left major fissure is also noted. There is bilateral peripheral sparing and mosaicism.
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected. DIP and hypersensitivity pneumonitis remained in the differential diagnosis
Ashley Davidoff MD TheCommonVein.net 251Lu 135925

Prominent Upper Lobe and
Superior Segments of the Lower Lobes
Central Ground Glass  Changes

CT 1month Later Prominent Central  Upper Lobe and Superior Segments of the Lower Lobes Ground Glass  Changes
55 year old male with substance use disorder presents with progressive and now more severe dyspnea. CT through the mid lung fields shows extensive upper lobe and superior segmental lower lobe ground glass changes with thickening of the interlobular septa giving the appearance of “crazy paving”. Thickening and irregularity of the major and middle fissures are also noted. There is bilateral peripheral sparing with a batwing distribution
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected. DIP and hypersensitivity pneumonitis remained in the differential diagnosis
Ashley Davidoff MD TheCommonVein.net 251Lu 135926
CT 1month Later Prominent Central  Upper Lobe and Superior Segments of the Lower Lobes Ground Glass  Changes
55 year old male with substance use disorder presents with progressive and now more severe dyspnea. CT through the mid lung fields shows extensive upper lobe and superior segmental lower lobe ground glass changes with thickening of the interlobular septa giving the appearance of “crazy paving”. Thickening and irregularity of the major and middle fissures are also noted. There is bilateral peripheral sparing with a batwing distribution
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected. DIP and hypersensitivity pneumonitis remained in the differential diagnosis
Ashley Davidoff MD TheCommonVein.net 251Lu 135927
CT 1month Later Prominent Upper Lobe Interstitial and Parenchymal Changes
55 year old male with substance use disorder presents with progressive and now more severe dyspnea. CT through the mid lung fields shows extensive upper lobe and superior segmental lower lobe ground glass changes with thickening of the interlobular septa giving the appearance of “crazy paving”. Thickening and irregularity of the major and middle fissures are also noted. There is bilateral peripheral sparing with a batwing distribution
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected. DIP and hypersensitivity pneumonitis remained in the differential diagnosis
Ashley Davidoff MD TheCommonVein.net 251Lu 135928

Close to Normal Lung Bases

CT 1month Later Close to Normal Lung Bases
55 year old male with substance use disorder presents with progressive and now more severe dyspnea. CT through the lower lung fields shows sparing of disease except for minor changes in the subsegmental airways which are mildly thickened.
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected. DIP and hypersensitivity pneumonitis remained in the differential diagnosis
Ashley Davidoff MD TheCommonVein.net 251Lu 135929

Normal Sized Heart
No CHF

CT 1month Later Normal Sized Heart
55-year-old male with substance use disorder presents with progressive and now more severe dyspnea. Axial CT through the heart shows no evidence of cardiomegaly to suggest heart failure. Specifically the left atrium is enlarged
Ashley Davidoff MD TheCommonVein.net 251Lu 135944
CT 1month Later Question LVH
55-year-old male with substance use disorder presents with progressive and now more severe dyspnea. Axial CT through the heart suggests left ventricular hypertrophy which sometimes is associated with cocaine use
Ashley Davidoff MD TheCommonVein.net 251Lu 135945

Enlarged Liver Steatosis

CT Enlarged Liver Steatosis
55 year old male with substance use disorder presents with progressive and now more severe dyspnea. CT through the upper abdomen shows an enlarged and mildly fatty liver.
Ashley Davidoff MD TheCommonVein.net 251Lu 135930
CT 1month Later Prominent Upper Lobe Ground Glass Parenchymal Changes
55-year-old male with substance use disorder presents with progressive and now more severe dyspnea. Coronal CT through the anterior lung fields shows upper lobe predominant ground glass changes with thickening of the interlobular septa giving the appearance of “crazy paving”. Thickening and irregularity of the right major fissures is noted.
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected. DIP and hypersensitivity pneumonitis remained in the differential diagnosis
Ashley Davidoff MD TheCommonVein.net 251Lu 135931
Prominent Upper Lobe and Superior Aspects of the Lower Lobe Ground Glass Parenchymal Changes
55-year-old male with substance use disorder presents with progressive and now more severe dyspnea. Coronal CT through the anterior lung fields shows upper lobe predominant ground glass changes with thickening of the interlobular septa. Thickening and irregularity of the right major fissures is noted.
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected. DIP and hypersensitivity pneumonitis remained in the differential diagnosis
Ashley Davidoff MD TheCommonVein.net 251Lu 135932
Prominent Upper Lobe and Superior Aspects of the Lower Lobe Ground Glass Parenchymal Changes
55-year-old male with substance use disorder presents with progressive and now more severe dyspnea. Coronal CT through the anterior lung fields shows upper lobe predominant ground glass changes with thickening of the interlobular septa and a “crazy paving” appearance is suggested. The superior segment of the right lower lobe is also involved. Thickening and irregularity of the right major fissures is noted. LVH is suggested.
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected. DIP and hypersensitivity pneumonitis remained in the differential diagnosis
Ashley Davidoff MD TheCommonVein.net 251Lu 135933
Prominent Upper Lobe and Superior Aspects of the Lower Lobe Ground Glass Parenchymal Changes
55-year-old male with substance use disorder presents with progressive and now more severe dyspnea. Coronal CT through the mid lung fields shows upper lobe predominant ground glass changes with thickening of the interlobular septa and a “crazy paving” appearance is suggested. The superior segments of the lower lobes are also involved. Thickening and irregularity of the right and left major fissures and the transverse fissure are noted. LVH is suggested.
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected. DIP and hypersensitivity pneumonitis remained in the differential diagnosis
Ashley Davidoff MD TheCommonVein.net 251Lu 135934
CT 1month Later Prominent Upper Lobe and Superior Aspects of the Lower Lobe Ground Glass Parenchymal Changes
55-year-old male with substance use disorder presents with progressive and now more severe dyspnea. Coronal CT through the mid lung fields shows upper lobe predominant ground glass changes with thickening of the interlobular septa and a “crazy paving” appearance is suggested. The superior segments of the lower lobes are also involved. Subpleural sparing is suggested. Thickening and irregularity of the right and left major fissures and the transverse fissure are noted.
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected. DIP and hypersensitivity pneumonitis remained in the differential diagnosis
Ashley Davidoff MD TheCommonVein.net 251Lu 135935
CT 1month Later CT 1month Later Prominent Upper Lobe Ground Glass Changes
55-year-old male with substance use disorder presents with progressive and now more severe dyspnea. Coronal CT through the posterior lung fields shows upper lobe predominant ground glass changes with thickening of the interlobular septa and a “crazy paving” appearance is suggested. The superior segments of the lower lobes are also involved. Subpleural sparing is suggested.
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected. DIP and hypersensitivity pneumonitis remained in the differential diagnosis
Ashley Davidoff MD TheCommonVein.net 251Lu 135936
CT 1month Later Prominent Upper Mid a Superior Segment of the Lower Lobe Interstitial and Parenchymal Changes
55-year-old male with substance use disorder presents with progressive and now more severe dyspnea. Sagittal CT through the right lung field shows ground glass changes in the upper mid and superior segment of the lower lobe. Subpleural sparing is suggested anteriorly. The fissures of the areas of involved lung are focally thickened
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected. DIP and hypersensitivity pneumonitis remained in the differential diagnosis
Ashley Davidoff MD TheCommonVein.net 251Lu 135937
CT 1month Later Prominent Upper Lobe Interstitial and Parenchymal Changes
55-year-old male with substance use disorder presents with progressive and now more severe dyspnea. Sagittal CT through the right lung field shows ground glass changes in the upper mid and superior segment of the lower lobe. The fissures of the areas of involved lung are focally thickened
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected. DIP and hypersensitivity pneumonitis remained in the differential diagnosis
Ashley Davidoff MD TheCommonVein.net 251Lu 135938
CT 1month Later Prominent Upper Lobe and Superior Aspects of the Lower Lobe Ground Glass Parenchymal Changes
55-year-old male with substance use disorder presents with progressive and now more severe dyspnea. Sagittal CT through the right lung field shows ground glass changes in the upper mid and superior segment of the lower lobe. The fissures of the areas of involved lung are focally thickened
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected. DIP and hypersensitivity pneumonitis remained in the differential diagnosis
Ashley Davidoff MD TheCommonVein.net 251Lu 135939
CT 1month Later Prominent Upper Lobe and Superior Aspects of the Lower Lobe Ground Glass Parenchymal Changes
55-year-old male with substance use disorder presents with progressive and now more severe dyspnea. Sagittal CT through the right lung field shows ground glass changes in the upper mid and superior segment of the lower lobe. The fissures of the areas of involved lung are focally thickened. There is subpleural sparing
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected. DIP and hypersensitivity pneumonitis remained in the differential diagnosis
Ashley Davidoff MD TheCommonVein.net 251Lu 135940
CT 1month Later Prominent Left Upper Lobe and Superior Segment of the Lower Lobe Ground Glass Parenchymal Changes
55-year-old male with substance use disorder presents with progressive and now more severe dyspnea. Sagittal CT through the left lung field shows ground glass changes in the upper mid and superior segment of the lower lobe. The fissures of the areas of involved lung are focally thickened. There is subpleural sparing.
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected. DIP and hypersensitivity pneumonitis remained in the differential diagnosis
Ashley Davidoff MD TheCommonVein.net 251Lu 135941
CT 1month Later Prominent Left Upper Lobe and Superior Segment of the Lower Lobe Ground Glass Parenchymal Changes
55-year-old male with substance use disorder presents with progressive and now more severe dyspnea. Sagittal CT through the left lung field shows ground glass changes in the upper mid and superior segment of the lower lobe. The fissures of the areas of involved lung are focally thickened. There is subpleural sparing.
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected. DIP and hypersensitivity pneumonitis remained in the differential diagnosis
Ashley Davidoff MD TheCommonVein.net 251Lu 135942
CT 1month Later Prominent Left Upper Lobe and Superior Segment of the Lower Lobe Ground Glass Parenchymal Changes
55-year-old male with substance use disorder presents with progressive and now more severe dyspnea. Sagittal CT through the left lung field shows ground glass changes in the upper mid and superior segment of the lower lobe. The fissures of the areas of involved lung are focally thickened. There is subpleural sparing and “crazy paving” pattern suggested with thickened interlobular septa.
Progressive inhalational pneumonitis from smoking or cocaine inhalation was suspected. DIP and hypersensitivity pneumonitis remained in the differential diagnosis
Ashley Davidoff MD TheCommonVein.net 251Lu 135943

Improved CT after 2 Months of Steroids

CT after 2 Months of Steroids
55-year-old male with substance use disorder presents with a history of inhalational pneumonitis likely from cocaine presents 2 months after treatment with steroids. Scout CT shows clear lungs
Ashley Davidoff MD TheCommonVein.net 251Lu 135946
CT after 2 Months of Steroids
55-year-old male with substance use disorder presents with a history of inhalational pneumonitis likely from cocaine presents 2 months after treatment with steroids. Axial CT through the upper lung fields show significant improvement with mild residual patchy ground glass change particularly in the left upper lobe
Ashley Davidoff MD TheCommonVein.net 251Lu 135948
CT after 2 Months of Steroids
55-year-old male with substance use disorder presents with a history of inhalational pneumonitis likely from cocaine presents 2 months after treatment with steroids. Axial CT through the upper lung fields show significant improvement with mild residual patchy ground glass change particularly in the left upper lobe
Ashley Davidoff MD TheCommonVein.net 251Lu 135948
CT after 2 Months of Steroids
55-year-old male with substance use disorder presents with a history of inhalational pneumonitis likely from cocaine presents 2 months after treatment with steroids. Coronal CT through the anterior lung fields show significant improvement with mild residual patchy ground glass change particularly in the left upper lobe with a single focus of mild bronchiectasis
Ashley Davidoff MD TheCommonVein.net 251Lu 135949
CT after 2 Months of Steroids
55-year-old male with substance use disorder presents with a history of inhalational pneumonitis likely from cocaine presents 2 months after treatment with steroids. Coronal CT through the carina shows significant improvement
Ashley Davidoff MD TheCommonVein.net 251Lu 135950