• Cellular NSIP

• NSIP can be divided into two subtypes based on the predominant histological pattern seen on lung biopsy: cellular NSIP and fibrotic NSIP.
  • In Cellular NSIP, the lung tissue is
  • relatively little fibrosis.
    • CT
      •  patchy or diffuse ground-glass opacities
      • may be associated with a reticular pattern and
      • traction bronchiectasis
      • more pronounced in the
        • peripheral regions of the lungs, and may be
        • subpleural or
        • peribronchovascular
          • may also be consolidation in some areas of the lung.

Predominant Ground Glass Pattern

• • In Fibrotic NSIP
    • presence of fibrosis or
    • scarring within the lung tissue.
    • worse prognosis c
    • more severe respiratory symptoms,
    • lower lung function, and a
    • greater likelihood of developing pulmonary hypertension.
      • CT
        • shows more pronounced and
        • diffuse reticular opacities and
        • traction bronchiectasis, with
        • less ground-glass opacities
        • fibrotic changes may be
          • more extensive and involve
          • larger areas of the lung tissue.
        • may also be
          • honeycombing in advanced cases.

References and Links

• TCV
  • NSIP Introduction
    • Cellular NSIP
    • Fibrotic NSIP
  • NSIP Cases 
  • ILD Map