232LU Possible Langerhan’s Cell Histiocytosis (PLCH) Inhalational Injury

Bronchiectasis (HCC-CMS)
Postinflammatory pulmonary fibrosis
Multiple pulmonary nodules
Seasonal allergic rhinitis

 

  • 63 y.o. female with a
  • history of
    • HTN, HLD, spinal stenosis,
    • LTBI s/p treatment,
    • T2DM,
    • breast CA s/p adjuvent XRT,
    • history of inhalation injury
      • inhalation injury about 15-20 years ago
      • hot gas blast of unknown source
        • walking down the street going to work and walked into this heat with a burning feeling.
        • blistered skin and
        • hair loss.
        • hospitalized at Boston City
      • smoking history
        • 2-3 cigarettes per day x
        • 25 years,
        • quit >15 years ago
      • PFT
        • PFTs have shown significant reduction in DLCO. TTE with
      • and abnormal CT,

CXR 2yrs After Injury showing Nodules in the RUL 

      • CXR 2yrs After Injury showing Nodules in the RUL
        Subsequent Diagnosis likely Langerhans Cell histiocytosis (PLCH)
        Ashley Davidoff TheCommonVein.net
        CXR 2yrs After Injury showing Nodules in the RUL
        Subsequent Diagnosis likely Langerhans Cell histiocytosis (PLCH)
        Ashley Davidoff TheCommonVein.net

        CT scan of the 2yrs After Injury showing Mosaic Attenuation

CT scan of the 2yrs After Injury showing Mosaic Attenuation
Subsequent Diagnosis likely Langerhans Cell histiocytosis (PLCH)
Ashley Davidoff TheCommonVein.net

CXR 4yrs After Injury showing No Significant Change in the Nodules in the RUL 

CXR 4yrs After Injury showing No Significant Change in the Nodules in the RUL 
Subsequent Diagnosis likely Langerhans Cell histiocytosis (PLCH)
Ashley Davidoff TheCommonVein.net
CXR 4yrs After Injury showing No Significant Change in the Nodules in the RUL 
Subsequent Diagnosis likely Langerhans Cell histiocytosis (PLCH)
Ashley Davidoff TheCommonVein.net

 

CT scan of the 5yrs After Injury showing Multiple Different Sized Cysts in the Upper Lobes and Diffuse Distribution of Micronodules Suggesting Small Airway Disease

CT scan of the 5yrs After Injury showing Multiple Different Sized Cysts in the Upper Lobes and Diffuse Distribution of Micronodules Suggesting Small Airway Disease
Subsequent Diagnosis likely Langerhans Cell histiocytosis (PLCH)
Ashley Davidoff TheCommonVein.net

CT scan of the 5yrs After Injury showing Multiple Different Sized Cysts in the Upper Lobes and  Micronodules Suggesting Small Airway Disease

CT scan of the 5yrs After Injury showing Multiple Different Sized Branching Cysts in the Upper Lobes and  Micronodules Suggesting Small Airway Disease

CT scan of the 5yrs After Injury showing Multiple Different Sized Branching Cysts in the Upper Lobes and  Micronodules Suggesting Small Airway Disease
Subsequent Diagnosis likely Langerhans Cell histiocytosis (PLCH)
Ashley Davidoff TheCommonVein.net
CT scan of the 5yrs After Injury showing Ground Glass Nodule with a Suggestion of Early Cavitation with Micronodules Suggesting Small Airway Disease
Subsequent Diagnosis likely Langerhans Cell histiocytosis (PLCH)
Ashley Davidoff TheCommonVein.net

CT scan of the 5yrs After Injury showing a  Cyst Alongside a Pulmonary Arteriole Reflecting Bronchiolectasis 

CT scan of the 5yrs After Injury showing A Cyst Alongside a Pulmonary Arteriole Reflecting Bronchiolectasis 
Subsequent Diagnosis likely Langerhans Cell histiocytosis (PLCH)
Ashley Davidoff TheCommonVein.net

CT scan of the 5yrs After Injury showing a  Thick Walled Small Airway with Bronchiolectasis 

CT scan of the 5yrs After Injury showing a  Thick Walled Small Airway with Bronchiolectasis 
Subsequent Diagnosis likely Langerhans Cell histiocytosis (PLCH)
Ashley Davidoff TheCommonVein.net

CXR 10 yrs After Injury showing No Significant Change in the Nodules in the RUL 

CXR 10 yrs After Injury showing No Significant Change in the Nodules in the RUL 
Subsequent Diagnosis likely Langerhans Cell histiocytosis (PLCH)
Ashley Davidoff TheCommonVein.net

CT scan of the 11yrs After Injury showing Multiple Different Sized Cysts in the Upper Lobes Not Significantly Changed and  Micronodules Suggesting Small Airway Disease

CT scan of the 11yrs After Injury showing Multiple Different Sized Branching Cysts in the Upper Lobes and  Micronodules Suggesting Small Airway Disease
Subsequent Diagnosis likely Langerhans Cell histiocytosis (PLCH)
Ashley Davidoff TheCommonVein.net

CT scan of the 11yrs After Injury showing Multiple Different Sized Branching Cysts in the Upper Lobes and  Micronodules Suggesting Small Airway Disease

CT scan of the 11yrs After Injury showing Multiple Different Sized Branching Cysts in the Upper Lobes and  Micronodules Suggesting Small Airway Disease
Subsequent Diagnosis likely Langerhans Cell histiocytosis (PLCH)
Ashley Davidoff TheCommonVein.net

 

CT scan of the 11yrs After Injury showing Persistent Mosaic Attenuation in the Lower Lung Fields  Suggesting Small Airway Disease

CT scan of the 11yrs After Injury showing Persistent Mosaic Attenuation in the Lower Lung Fields
Subsequent Diagnosis likely Langerhans Cell histiocytosis (PLCH)
Ashley Davidoff TheCommonVein.net

CT scan of the 11yrs After Injury showing Persistent Mosaic Attenuation in the Lower Lung Fields and Micronodules Suggesting Small Airway Disease

CT scan of the 11yrs After Injury showing Persistent Mosaic Attenuation in the Lower Lung Fields and Micronodules Suggesting Small Airway Disease
Subsequent Diagnosis likely Langerhans Cell histiocytosis (PLCH)
Ashley Davidoff TheCommonVein.net

CT scan of the 12yrs After Injury showing mostly Stable  Multiple Different Sized Cysts in the Upper Lobes and  Micronodules Suggesting Small Airway Disease

CT scan of the 12yrs After Injury showing mostly Stable  Multiple Different Sized Cysts in the Upper Lobes and  Micronodules Suggesting Small Airway Disease
Subsequent Diagnosis likely Langerhans Cell histiocytosis (PLCH)
Ashley Davidoff TheCommonVein.net
CT scan of the 12yrs After Injury showing mostly Stable  Multiple Different Sized Cysts in the Upper Lobes and  Micronodules Suggesting Small Airway Disease
Subsequent Diagnosis likely Langerhans Cell histiocytosis (PLCH)
Ashley Davidoff TheCommonVein.net

 

CT scan of the 13yrs After Injury showing Slightly Progressive Reticulations and Stable  Multiple Different Sized Cysts in the Upper Lobes and  Micronodules Suggesting Small Airway Disease

CT scan of the 13yrs After Injury showing Slightly Progressive Reticulations and Stable  Multiple Different Sized Cysts in the Upper Lobes and  Micronodules Suggesting Small Airway Disease
Subsequent Diagnosis likely Langerhans Cell histiocytosis (PLCH)
Ashley Davidoff TheCommonVein.net

CXR 20 yrs After Injury showing Mild Increase in the Reticular Changes and No Significant Change in the  in the Nodules in the RUL 

    • CXR 20 yrs After Injury showing Mild Increase in the Reticular Changes and No Significant Change in the  in the Nodules in the RUL
      Subsequent Diagnosis likely Langerhans Cell histiocytosis (PLCH)
      Ashley Davidoff TheCommonVein.net