• Smoking Related ILD
  • • Smoking related
      • small airways
      • upper lung fields
      • interstitial changes fibrosis
    • ILD
      • restrictive lung disease
      • impaired gas exchange
    • 3 Major Groups
      • Group 1
        • Respiratory bronchiolitis ILD (RB-ILD)
        • Pulmonary Langerhans cell histiocytosis (PLCH).
        • Desquamative interstitial pneumonitis (DIP), and
      • Group 2
        • Acute ILD
        • smoking seems to have an important pathogenetic role, although to a lesser extent than in the first group
          • acute eosinophilic pneumonia and
          • pulmonary hemorrhage syndrome,
      • Group 3
      • , diseases in which smoking  creates an increased risk for developing
        • Idiopathic pulmonary fibrosis (IPF) UIP. The combination of lower lung fibrosis and upper lung emphysema is being increasingly recognized as a distinct clinical entity in smokers. High-resolution computed t
        • Rheumatoid arthritis-related ILD (RA-ILD)
      • Group 4
        • diseases that are actually less likely to develop in smokers .  The protective effect of smoking in these diseases may result from suppression of T-helper cell (Th)1 immunity
          • Sarcoidosis
            •  Nonetheless,
              • when smokers develop the disease
              • outcome is worse than in nonsmokers
          •  Hypersensitivity pneumonitis
      •  Others
        • Alveolar Proteinosis

Links and References

Ryu J.H. et al Smoking-related interstitial lung diseases: a concise review European Respiratory Journal 2001 17: 122-132;

 Margaritopoulos, G A. et al Smoking and interstitial lung diseases European Respiratory Review 2015 24: 428-435; 2015

Smoking related ILD