Structure Subsegmental Bronchi Overview of the Anatomy of the Lungs Large Airways and Small AirwaysThis image shows the division of the airways in the lungs classified as large airways and small airways.A large airway is considered any airway larger than 2mm, and therefore includes all the airways involved with transport of air except for the terminal bronchiole. Included as seen in image a, are the trachea, mainstem bronchi, lobar bronchi segmental and subsegmental airways and the 3 subsequent divisions of subsegmental bronchi and bronchioles till the last transporting airway – the respiratory bronchiole which is usually about 2mm and is considered a small airway Image (a) shows the airways starting in the trachea and continuing to the mainstem bronchi, lobar bronchi, segmental bronchi, and subsegmental bronchi.Image b shows the structures that make up the small airways starting with the terminal bronchiole (tb) followed by the respiratory bronchiole (rb) alveolar duct, (ad) and alveolar sacs (as)Image (c) shows the histologic makeup of the large airways that include a pseudostratified ciliated columnar epithelium with mucus secreting goblet cells a muscular layer (red) and a prominent cartilage layer (white) In the larger bronchioles (d) the epithelium remains as a pseudostratified, ciliated, columnar epithelium with prominent muscular layer (red). The columnar epithelium transitions to a stratified ciliated cuboidal epithelium by the terminal bronchiole s (f) both still with a muscular layer. The respiratory epithelium transitions from a cuboidal epithelium to a squamous epithelium (f) with alveoli and type I and II pneumocytes starting to branch (g) Ashley Davidoff MD TheCommonVein.net lungs-0740nL Keywordslungs airways segmental subsegmental small airway disease micronodulesAshley Davidoff MDTheCommonVein.net Segmental and Subsegmental airway disease with Wall ThickeningAshley Davidoff MDTheCommonVein.net CHF 50 year old female with diabetes, chronic renal failure with congestive heart failure. CT in the coronal plane shows diffuse ground glass changes, Kerley B lines peribronchial cuffing in the right upper lobe and right lower lobeAshley Davidoff MD TheCommonvein.net 50-004-CT 50 year old female with diabetes, chronic renal failure with congestive heart failure. CT in the coronal plane shows diffuse ground glass changes, peribronchial cuffing and mosaic attenuationAshley Davidoff MD TheCommonvein.net 50-005-CT 50 year old female with diabetes, chronic renal failure with congestive heart failure. CT in the axial plane shows diffuse ground glass changes, mild mosaic attenuation changes bilaterally, and a complex right effusionAshley Davidoff MD TheCommonvein.net 50-009-CT 50 year old female with diabetes, chronic renal failure with congestive heart failure. CT in the axial plane shows diffuse ground glass changes, thickening of the interlobular septa, centrilobular nodules peribronchial cuffing mosaic attenuation in the right lower lobe, associated with a complex right sided effusionAshley Davidoff MD TheCommonvein.net 50-010-CT Chemotherapy CT post chemo shows left lower lobe subsegmental infiltrate, ground glass pattern and thickening of the subsegmental airways in the lower lobesthecommonvein.netAshley Davidoff MD Amyloidosis Amyloid Involving the AirwaysAxial CT image shows involvement of known amyloid in the trachea (a,b,c,d) as well as the segmental and subsegmental airways (d,e,f)Ashley Davidoff MDTheCommonVein.net amyloid-airways-001b Amyloid in the Segmental and Subsegmental AirwaysAshley DavidoffTheCommonVein.net 44f Amyloid airways 004 Miliary TB Micronodules Right Upper Lobe Thickening of the Bronchioles68 year old female presented with malaise night sweats weight loss QuantiFeron gold positive, with a past history of treated TB in her native country as a child. Axial CT images through the upper lobe shows a miliary pattern of disease affecting interlobular septa along the venules , centrilobular and tree in bud nodular patterns. Bronchoscopy isolated Mycobacterium complex. She was treated with good resultAshley Davidoff MD TheCommonVein.net mycobacterium-complex-TB-68-004 Micronodules Right Upper Lobe Thickening of the Bronchioles68 year old female presented with malaise night sweats weight loss QuantiFeron gold positive, with a past history of treated TB in her native country as a child. Axial CT images through the upper lobe shows a miliary pattern of disease affecting interlobular septa along the venules , centrilobular and tree in bud nodular patterns. Bronchoscopy isolated Mycobacterium complex. She was treated with good resultAshley Davidoff MD TheCommonVein.net mycobacterium-complex-TB-68-005 Aspergillosis Bronchopneumonic Form of Aspergillosis43 year old man with known aspergillus infection. Note the thickening of the walls of the segmental subsegmental and small airways with extensive tree in bud changes and bronchial wall thickening. There are centrilobular nodules indicating the small airway diseaseAshley Davidoff MD TheCommonVein.net117816c CVID small airway disease with segmental and subsegmental wall thickeningAshley Davidoff MD TheCommonvein.net CVID small airway disease 006 Metastatic Breast Carcinoma Tumor emboli from breast carcinoma in a 52-year-old woman. High-resolution CT scans show enlarged and beaded subsegmental arteries in the lower lobes. Note the peripheral tree-in-bud opacities.Rossi, SE et al Tree-in-Bud Pattern at Thin-Section CT of the Lungs: Radiologic-Pathologic Overview RadioGraphicsVol. 25, No. 3 2005 Eosinophillic Pneumonia CT scan shows bilateral subsegmental infiltrates both along the bronchovascular bundle as well s peripherally in the lower lobes, lingula and middle lobe. The upper lobes are involved to lesser degreeAshley Davidoff MDTheCommonVein.net Asbestosis 72 year old man with asbestosis. Chest Xray (a) shows diffuse reticular changes, dominant in the lower lobes and with a “shaggy” heart border, implying involvement of the middle lobe and lingular segments. Image b is an axial slice at the level of the main pulmonary artery and shows calcified pleural plaques in the posteromedial and right anteromedial locations. Image c of the upper lung zones show mild reticular changes and honeycomb changes. Image d shows reticular changes, more dense fibrotic changes in the lingula, thickening along right lower lobe subsegmental airway and early honeycombingAshley Davidoff MD thecommonvein.net 47060c01keywords chest lung fx shaggy heart border reticular changes interstitial lung disease interstitium honeycombing pleural calcification fibrosis dx asbestosis