- Common reasons
-
- Larger volume
- Gravity
- Increased oxygen tension
- increase oxidative stress
- Increased lymphatics
- Decreased perfusion
- Gas exchange is more efficient in the lower lobes
- Blood Flow is higher in the lower lobes
-
- Inhalational
- Centrilobular emphysema.
- TB
- InhaledParticlates
- Silicosis
- Berylliosis
- Pneumoconnioses
- Hypersensitivity Pneumonitis
- Allergic Bronchopulmonary Aspergillosis
- Sarcoidosis
- Langerhans Cell Histiocytosis
- Bronchocentric Granulomatosis
- Chronic Eosinophilia
- (peripheral and upper lobes)
- Cocaine
- Adenocarcinoma
TB
Left image: In this patient with TB there is a linear band like density with calcifications in the LUL characteristic of atelectatic change in the LUL. This loss of volume is associated with fibrosis and retraction seen on the CXR in the following image. Courtesy of: Ashley Davidoff, M.D.
Sarcoidosis
SARCOIDOSIS vs SILICOSIS
42-year-old cement worker presents with dyspnea .
A CXR performed 5 years prior was close to normal with possible right hilar prominence.
The CT scan, shows diffuse micronodular lung disease, predominantly in the upper lobes with mediastinal widening consistent with mediastinal lymphadenopathy, dominant in the right paratracheal region and in the subcarinal region.
Lung windows show the presence of extensive diffuse micronodular disease accumulating along lymphatics along fissures and pleural surfaces, and along the bronchovascular bundles. Although there is diffuse disease, the upper lobes are slightly more involved than the lower lobes. The extensive thickening along bronchovascular bundles and prominent adenopathy favors a diagnosis of sarcoidosis but with a work history of being a cement worker, silicosis still remains in the differential diagnosis as a less likely possibility.
Ashley Davidoff MDLangerhans Cell Histiocytosis