Diagrams Secondary Lobule

The Secondary Lobule
The secondary lobule is subtended by the  lobular arteriole (a) and the lobular bronchiole (b) which  which in turn branches into the respiratory bronchioles, alveolar ducts, and nd alveolar sacs (c)  The acinus (d) consists of a respiratory bronchiole and its associated alveolar ducts, sacs, and alveoli and represents the functional unit of the lung.
The secondary lobule is drained by the pulmonary venule (e) which runs in the interlobular septum also containing the lymphatics (f).  The whole unit is housed and surrounded by a connective tissue framework (g)  . The latter 3 structures form the interlobular septum.
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Secondary Lung Lobule
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Secondary Lung Lobule
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Collage of the Secondary Lobule 
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Secondary Lobule Gross Anatomy
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Secondary Lobule
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Secondary Lobule   
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Secondary lobule
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Alveoli in an Acinus of a Secondary Lobule
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Small Airways
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Secondary lobule
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Secondary lobule
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Overview of the Anatomy of the Lungs
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Small Airways
The diagram allows us to understand the the components and the position of the small airways starting in (a) which is a secondary lobule that is fed by a lobular bronchiole(lb) which enters into the secondary lobule and divides into terminal bronchioles (tb) which is the distal part of the conducting airways, and  at a diameter of Ashley Davidoff MD TheCommonVein.net lungs-0744
Small Airways
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The Secondary Lobule
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The Secondary Lobule
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The Superficial and Deep Lymphatic Systems at the Secondary Lobular Level

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The Superficial and Deep Lymphatic Systems at the Secondary Lobular Level
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Diseases

NSIP

Position and Nature of NSIP
Broncho vascular and inter- alveolar interstitial fibrosis dominantly in the lower lobes but affecting the middle and upper lobes to lesser extent resulting in bronchiectasis and reticulations.  The overall increase in density results in ground glass changes 
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Alveolar Proteinosis

Accumulation of proteinaceous material in the alveoli, impairing gas exchange and leading to respiratory failure. Extensive thickening of interlobular septa leading to crazy paving appearance.  Half filled alveoli lead to ground glass appearance
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Honeycomb 

Honeycomb Lung
In patients with interstitial lung  disease, the  inflammatory process and interstitial fibrotic disease  progresses and the walls between the alveoli are destroyed causing large subpleural, variably sized, subpleural, thick walled, stacked, cystic spaces . The appearance is reminiscent of a honeycomb and indicates end stage fibrosis
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Interstitial Interalveolar Fibrosis

Intralobular, interstitial – interalveolar fibrosis (white) between the alveoli
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Alveolitis

Interstitial changes (red parts of alveoli ) representing either infiltration into the interstitium or inflammatory changes in the interalveolar interstitium
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Alveolitis and Inflammation of the Interlobular Septa

Alveolitis
Diagram shows inflammation (red ) in the walls of the alveoli with thickening of the interlobular septa (maroon) . The increased density in the interalveolar septa and interlobular septa results in a ground glass opacity with and crazy paving appearance on CT scan
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Alveolitis

Alveolitis
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Alveolitis

Alveolitis
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Thickening of the Interlobular Septa – Crazy Paving Kerley B lines
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Eosinophilic Pneumonia

The Secondary Lobule in Acute Eosinophilic Pneumonia (AEP)
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Acute Eosinophillic Pneumonia
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Acute Eosinophillic Pneumonia
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Acute Eosinophillic Pneumonia
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Advancing Acute Eosinophilic Pneumonia
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